Dysprosium oxide, alumina, and graphene oxide reinforced polycaprolactone thin films: Thermal stability, morphology, and cell viability

• Published in: Journal of rare earths 2024-07, Vol.42 (7), p.1337-1343
• Main Authors: Elabbasy, Mohamed Tharwat, Atteya, Mohamed R., Samak, Mai A., Abdelrahman, Mousa, AlMahmoud, Tahani, El-Morsy, M.A., Menazea, A.A., Abd El-Kader, M.F.H.
• Format: Article
• Language: English
• Subjects: Al2O3; Biocompatible; Dy2O3; Polycaprolactone; Rare earths; Wound healing
• ISSN: 1002-0721; 2509-4963
• DOI: 10.1016/j.jre.2023.08.013

Developing a biomaterial for wound healing applications is still a challenge. Herein, dysprosium oxide (Dy2O3), aluminum oxide (Al2O3), and graphene oxide (GO) were embedded in cast films based on polycaprolactone (PCL) to be examined for wound dressing usage. Different techniques were used to characterize the fabricated films including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman, and scanning electron microscopy (SEM), besides their biological activity. The thermogravimetric analysis (TGA) exhibits high thermal stability as the scaffold weight decreases slightly to 98.6% after raising the temperature from room temperature to 280 °C. The cell viability was investigated and it is shown that the viable cells grow up to approximately 93% at 75 μg/mL. Meanwhile, the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility. The Dy2O3, Al2O3 and/or GO nanoparticles were embedded through polycaprolactone films, producing a thin film able to act as a bandage functionalized for wound dressing applications. [Display omitted]