Efficient crossover designs in the presence of interactions between direct and carry-over treatment effects

• Published in: Journal of statistical planning and inference 2011-02, Vol.141 (2), p.846-860
• Main Authors: Park, D.K., Bose, Mausumi, Notz, W.I., Dean, A.M.
• Format: Article
• Language: English
• Subjects: A-optimality; Applications; Carry-over effects; Combinatorics; Combinatorics. Ordered structures; Crossover designs; D-optimality; Designs and configurations; Direct effects; Efficiency; Exact sciences and technology; Experimental design; General topics; Mathematics; Medical sciences; Probability and statistics; Residual effects; Sciences and techniques of general use; Statistics
• ISSN: 0378-3758; 1873-1171
• DOI: 10.1016/j.jspi.2010.08.005

Crossover designs, or repeated measurements designs, are used for experiments in which t treatments are applied to each of n experimental units successively over p time periods. Such experiments are widely used in areas such as clinical trials, experimental psychology and agricultural field trials. In addition to the direct effect on the response of the treatment in the period of application, there is also the possible presence of a residual, or carry-over, effect of a treatment from one or more previous periods. We use a model in which the residual effect from a treatment depends upon the treatment applied in the succeeding period; that is, a model which includes interactions between the treatment direct and residual effects. We assume that residual effects do not persist further than one succeeding period. A particular class of strongly balanced repeated measurements designs with n= t 2 units and which are uniform on the periods is examined. A lower bound for the A-efficiency of the designs for estimating the direct effects is derived and it is shown that such designs are highly efficient for any number of periods p=2,…,2 t.