Rapidly Resolving and Recurrent Contralateral Subdural Hematoma From Disseminated Intravascular Coagulation

• Published in: Journal of stroke and cerebrovascular diseases 2020-08, Vol.29 (8), p.104872, Article 104872
• Main Authors: Al Shaikh, Rana Hanna, Hasan, Tasneem F., Becker, Tara L., Ng Tucker, Lauren K., Meschia, James F., Tawk, Rabih G., Ayala, Ernesto, Freeman, William D.
• Format: Article
• Language: English
• Subjects: Atraumatic; Contralateral; Disseminated intravascular coagulation; Malignancy; Rapidly resolving; Recurrent; Spontaneous; Subdural hematoma
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2020.104872

•Rapidly resolving and recurrent, contralateral acute subdural hematoma is a rare entity in the absence of trauma.•Atraumatic subdural hematoma is a rare complication of disseminated intravascular coagulation.•Disseminated intravascular coagulation can present secondary to metastatic cancer.•Spontaneous resolution followed by recurrence of acute subdural hematoma can be associated with disseminated intravascular coagulation secondary to intracranial metastatic cancer. Acute, recurrent subdural hematoma (SDH) is a rare entity in the absence of trauma. Atraumatic SDH may be due to vascular disorders, coagulopathies, or intracranial hypotension. It is a rare complication of disseminated intravascular coagulation (DIC), with no prior reports in patients with intracranial metastatic colon cancer (MCC). Rapid resolution of the initial acute SDH with contralateral recurrence has not yet been reported in the literature. We present a case of rapidly resolving and recurrent, contralateral acute SDH from DIC secondary to MCC. A 77-year-old woman with MCC presented with severe, acute onset headache. She progressed to unresponsiveness, dilated right pupil, and Glasgow Coma Scale (GCS) score of 4T. Initial computed tomography (CT) of the head demonstrated a right, 17-mm SDH with a right-to-left midline shift. Repeat CT head 8 hours later revealed resolution of the right SDH. She was extubated with notable clinical improvement. Laboratory examination showed international normalized ratio of 3.4, leukocytosis, and thrombocytopenia. The next morning, she became lethargic, GCS score of 3, with bilateral fixed pupils and dilated to 5-mm, and she was then reintubated. Repeat CT head demonstrated a new left SDH with bilateral uncal herniation. A small hyperdense focus in the left parietal region was suspicious for intraparenchymal hematoma versus a hemorrhagic metastatic focus. Shortly after, she was extubated due to do not resuscitate status, and she then passed away. To our knowledge, this is the first case illustrating rapidly resolving and recurrent, contralateral acute SDH from DIC in a patient with MCC. Clinical recognition of this phenotypic pattern should raise the question of an underlying coagulopathy.