Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice

We evaluated tissue changes associated with cerium chloride administration via gavage to adult mice, via milk to neonatal mice and transplacentally to fetal mice. Change in adults consisted of extensive pulmonary hemorrhage, pulmonary venous congestion, thickened alveolar septae, hepatic necrosis an...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology 2008-01, Vol.22 (1), p.59-65
Main Authors: Kawagoe, Masami, Ishikawa, Kiyoshi, Wang, Shou-Cun, Yoshikawa, Kiwamu, Arany, Szilvia, Zhou, Xiao-Ping, Wang, Jing-Shu, Ueno, Yasuharu, Koizumi, Yukio, Kameda, Takashi, Koyota, Souichi, Sugiyama, Toshihiro
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Animals, Newborn
Anticoagulants - administration & dosage
Anticoagulants - pharmacology
Cerium
Cerium - administration & dosage
Cerium - pharmacology
Clotting time
Dose-Response Relationship, Drug
Fetus
Hemorrhage
Liver - drug effects
Liver - pathology
Lung - drug effects
Lung - pathology
Mice
Mice, Inbred ICR
Neonate
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Summary:We evaluated tissue changes associated with cerium chloride administration via gavage to adult mice, via milk to neonatal mice and transplacentally to fetal mice. Change in adults consisted of extensive pulmonary hemorrhage, pulmonary venous congestion, thickened alveolar septae, hepatic necrosis and neutrophil infiltrations. Those in fetal mice consisted of pulmonary and hepatic congestion. These results indicate that gavage cerium administration elicited subtle tissue changes, though oral toxicity is rather low. These changes were less severe in neonatal and fetal mice. When cerium was injected into adult mice through the tail vein, cerium was distributed mainly to the liver, spleen and lung dose-dependently with the cerium concentration gradually decreasing after 3 days. A study of cerium anticoagulation in mouse plasma showed that clotting time was significantly prolonged when cerium was added to plasma. These results suggest that cerium may disturb blood coagulation and cause pulmonary and hepatic vascular congestion.
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2007.08.003