Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome

The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats. Assessment of gravimetric, hormonal pr...

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Bibliographic Details
Published in:	Life sciences (1973) 2022-04, Vol.295, p.120086, Article 120086
Main Authors:	Ghosh, Hindole, Rai, Seema, Manzar, Md Dilshad, Pandi-Perumal, Seithikurippu R., Brown, Gregory M., Reiter, Russel J., Cardinali, Daniel P.
Format:	Article
Language:	English
Subjects:	Animals Disease Models, Animal Estrogen Receptor alpha - metabolism Estrogen Receptor alpha - physiology estrogen receptors Female Gene Expression - genetics gene expression regulation Gene Expression Regulation - drug effects Gene Expression Regulation - genetics gonadotropins Gonadotropins - metabolism histology Hyperthyroid hyperthyroidism Hyperthyroidism - metabolism Hypothyroid iodide peroxidase L-thyroxine Letrozole - pharmacology Melatonin Melatonin - metabolism Melatonin - pharmacology Ovary - metabolism Ovary - physiology pathogenicity PCOS polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Rats Rats, Wistar Receptors, Thyroid Hormone - metabolism Receptors, Thyroid Hormone - physiology testosterone Testosterone - metabolism Thyroid Gland - drug effects thyroid hormone receptors Thyroid Hormones - metabolism Thyroxine Thyroxine - metabolism triiodothyronine
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