Prevalence of pathogenic or likely pathogenic germline variants in cancer predisposition genes among selected patients with lung adenocarcinoma: The GERMLUNG study

[Display omitted] •A high pathogenic or likely pathogenic germline variants prevalence was identified based on our selection criteria.•Pathogenic or likely pathogenic germline variants were associated with male sex, and a trend to association with somatic actionable genomic alterations. Pathogenic o...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2024-08, Vol.194, p.107864, Article 107864
Main Authors: Arrieta, Oscar, Caballé-Pérez, Enrique, Hernández-Pedro, Norma, Romero-Nuñez, Eunice, Lucio-Lozada, José, Castillo-Ruiz, Cesar, Acevedo-Castillo, Karla, María Álvarez-Gómez, Rosa, Molina-Garay, Carolina, Jiménez-Olivares, Marco, Carrillo-Sánchez, Karol, Cristina Mendoza-Caamal, Elvia, Cardona, Andrés F., Remon, Jordi, Alaez-Verson, Carmen
Format: Article
Language:English
Subjects:
Actionable genomic alterations
Adenocarcinoma of lung
Adenocarcinoma of Lung - epidemiology
Adenocarcinoma of Lung - genetics
Adenocarcinoma of Lung - pathology
Adult
Aged
Checkpoint Kinase 2 - genetics
Cohort Studies
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Genetic Testing - methods
Germ-Line Mutation
Germline Pathogenic/Likely pathogenic variants
Hereditary
Humans
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Middle Aged
Neoplastic syndromes
Prevalence
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