Enhancing antimicrobial efficacy: 8-Hydroxyquinoline incorporation into metal-organic frameworks with iron ion coupling

• Published in: Materials chemistry and physics 2024-06, Vol.319, p.129346, Article 129346
• Main Authors: Nguyen, Linh Ho Thuy, Tran, Khoa Dang Hoang, Le, Tien My Thi, Nguyen, Vinh Phuoc, Vu, Giang Bac Nguyen, Tran, Phuong Hoang, Ung, Thuy Dieu Thi, Pham, Anh Tuan Thanh, Tran, Ngoc Quang, Le Minh, Tri, Doan, Tan Le Hoang
• Format: Article
• Language: English
• Subjects: 8-Hydroxyquinoline; Antimicrobial activity; Liquid adsorption; Metal chelate; Metal-organic frameworks
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2024.129346

The antimicrobial properties of 8-Hydroxyquinoline (8-Hq), a small organic compound known for its metal-chelating capabilities, hold significant promise. However, its limited solubility in water poses a challenge for practical applications. In this study, we address this limitation by augmenting the antimicrobial efficacy of 8-Hq through its integration into the metal-organic framework UiO-66 (named 8-Hq@UiO-66) and coupling it with iron ions (designated as Fe/8-Hq@UiO-66) via an adsorption process. The sorption isotherm and adsorption kinetics were meticulously examined using Langmuir's adsorption model and the pseudo-second-order kinetic model. Material characterization techniques including powder X-ray powder diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, nitrogen adsorption isotherms, ultraviolet–visible spectroscopy, and photoluminescence spectroscopy revealed the coordination of zirconium clusters and iron with the nitrogen and hydroxyl groups of 8-Hq, respectively. Furthermore, our investigation into metal ion adsorption demonstrated that the 8-Hq@UiO-66 composite displayed a notable selectivity for iron ions over other metal ions in aqueous media. Under optimized conditions, the adsorption capacity for iron ions ranged from approximately 34–46 mg g−1. Importantly, the Fe/8-Hq@UiO-66 composite exhibited potent antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. These findings underscore the potential of incorporating 8-Hq into porous metal-organic frameworks and coupling it with iron ions to enhance its antimicrobial efficacy. [Display omitted] •Enhanced antimicrobial efficacy via 8-Hq and iron ion integration into UiO-66.•Insights from sorption isotherms and kinetics models.•Selective conjugation of iron ions by 8-Hq@UiO-66.•Potent antimicrobial activity against diverse bacterial strains demonstrated.