Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

• Published in: Materials & design 2018-02, Vol.140, p.37-44
• Main Authors: Vakifahmetoglu, Cekdar, Zeydanli, Damla, Ozalp, Veli Cengiz, Borsa, Barış Ata, Soraru, Gian Domenico
• Format: Article
• Language: English
• Subjects: Hierarchical porous ceramics; High surface area; Multi drug (cargo) delivery/release system
• ISSN: 0264-1275; 1873-4197
• DOI: 10.1016/j.matdes.2017.11.047

Mesoporous silicon oxycarbide (SiOC) components were formed with the use of “molecular spacer” (a sacrificial vinyl-terminated linear siloxane which while decomposing during pyrolysis generates pores with size proportional to the molecular weight), followed by a post-pyrolysis etching treatment by hydrofluoric acid (HF) to obtain C-rich SiOC samples having additional micro-/mesoporosity and specific surface area reaching to 774m2/g. The biocompatibility of the samples was validated by hemolysis test, and their cargo/drug loading capacities were studied by two different sized polypeptides as model molecules. SiOC particles showed less hemolysis compared to the reference material MCM-41. Similarly, the loading capacity and the release kinetics of bovine serum albumin (BSA) and vancomycin-loaded SiOC particles were improved compared to that of MCM-41. In the multi cargo loading/release capacity tests, done by using different sized molecules, Bio2-HF and MCM-41 were loaded both with fluorescein and BSA. While a lagging time in fluorescein release was observed for MCM-41, the release kinetics of fluorescein and BSA was not affected when they are loaded together in the hierarchical pores of Bio2-HF, allowing the release of both large and small cargo molecules. The antimicrobial activity tests showed that Bio2-HF performed better than MCM-41 particles in improving bactericidal activity. [Display omitted] •SiOC ceramics were fabricated by a simple technique to obtain high surface area (reaching 774m2/g) hierarchical porosity.•Porous SiOC material were found to be biocompatible with less hemolysis than MCM-41.•The loading capacity and the release kinetics of cargo loaded SiOC were better than that of MCM-41.•It was demonstrated that hierarchical porosity ceramic can be used to carry different sized drug molecules.•The antimicrobial activity tests show that SiOC performs better than MCM-41 in improving bactericidal activity.