Resorbable hollow phosphate glass fibres as controlled release systems for biomedical applications

Controlled release systems are an attractive solution for the administration of biologically active molecules in a specific target site avoiding the drawbacks associated to drug oral administration. In this study phosphate glass hollow fibres were fabricated using a drawing tower and their ability t...

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Bibliographic Details
Published in:Materials letters 2013-05, Vol.99, p.125-127
Main Authors: Novajra, G., Lousteau, J., Milanese, D., Vitale-Brovarone, C.
Format: Article
Language:English
Subjects:
bioactive properties
biocomposites
Biomaterials
capillarity
Dissolution
Drug delivery
Fibre technology
glass
Hollow fibres
oral administration
Phosphate glasses
resorption
solubility
tissue engineering
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Summary:Controlled release systems are an attractive solution for the administration of biologically active molecules in a specific target site avoiding the drawbacks associated to drug oral administration. In this study phosphate glass hollow fibres were fabricated using a drawing tower and their ability to incorporate and release a test solution was investigated. The results showed that the hollow fibres can be easily filled with an aqueous solution exploiting the capillary action and they are able to subsequently release it from the fibre ends. The solubility of phosphate glass allows for fibre resorption during the release process. These fibres are promising resorbable carriers of bioactive molecules for controlled release devices, in the tissue engineering field and for the synthesis of biocomposite materials. ► Resorbable hollow glass fibres are proposed for the controlled release of drugs. ► Fibre drawing process with a precise control over the fibre dimensions is reported. ► Easy filling of the fibres with a solution exploiting the capillary action is verified. ► The release kinetics of the solution from the fibres ends is studied. ► Potential applications for resorbable phosphate glass hollow fibres are discussed.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2013.02.076