Green & sustainable nanocatalysed synthetic route for an exploration of knoevenagel condensation

Indole-3-carbaldehyde has a wide variety of applications, as a versatile synthon in organic chemistry, also found to be remarkably active as 12- & 15- lipoxygenase inhibitors, anti-tumour, antimicrobial and anti-inflammatory agents. In this work, we report the synthesis of targeted knoevenagel c...

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Bibliographic Details
Main Author: Madan, Yogita
Format: Conference Proceeding
Language:English
Subjects:
3-Formylindole
Green chemistry
Grindstone technology
Knoevenagel condensation
ZnO nanocatalyst
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Summary:Indole-3-carbaldehyde has a wide variety of applications, as a versatile synthon in organic chemistry, also found to be remarkably active as 12- & 15- lipoxygenase inhibitors, anti-tumour, antimicrobial and anti-inflammatory agents. In this work, we report the synthesis of targeted knoevenagel condensed products of indole-3-carbaledehydes (1a–e) and active methylene containing moieties 3-methyl-1-phenyl-5-pyrazolone (A) in the presence of ZnO nanoparticles by using solvent free grindstone method and compared with traditional refluxing method. Grindstone method for preparation of libraries of these knoevenagel condensed products lead to many advantages in terms of excellent yields, short reaction time, high reaction rate and also attracts the attention from the environment point of view as well as economic perspective. All the synthesized compounds have been characterized by their IR, 1H NMR, and Q-TOF mass spectral data and elemental analyses.
ISSN:2214-7853
2214-7853
DOI:10.1016/j.matpr.2020.04.037