Palladium-catalyzed carbonylative synthesis of quinazolines: Silane act as better nucleophile than amidine

•A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines.•Quinazolines were obtained in moderate to good yields from N-(2-iodophenyl)benzimidamide.•Silane act as better nucleophile than amine. A palladium-catalyzed reductive carbonylation reaction...

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Bibliographic Details
Published in:Molecular catalysis 2021-06, Vol.509, p.111627, Article 111627
Main Authors: Lu, Jia-Ming, Huo, Yong-Wang, Qi, Xinxin, Wu, Xiao-Feng
Format: Article
Language:English
Subjects:
Aromatic aldehyde
Carbonylation
N-(2-iodophenyl)benzimidamide
Palladium catalyst
Quinazoline
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Summary:•A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines.•Quinazolines were obtained in moderate to good yields from N-(2-iodophenyl)benzimidamide.•Silane act as better nucleophile than amine. A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines. With N-(2-iodophenyl)benzimidamide as starting materials, a series of quinazolines were obtained through the aromatic aldehyde intermediates in moderate to good yields with good functional group compatibilities. In this system, silane act as better nucleophile than amidine. [Display omitted]
ISSN:2468-8231
2468-8231
DOI:10.1016/j.mcat.2021.111627