Impact of high-flow oxygen therapy via high velocity nasal insufflation on diaphragmatic thickening fraction in healthy subjects

• Published in: Medicina intensiva 2024-12, Vol.48 (12), p.686-692
• Main Authors: Plotnikow, Gustavo Adrián, Bianchini, Facundo José Federico, Moracci, Roque, Santana Mackinlay, Jaime Andrés, Melgarejo, Federico, Loustau, Malena Paula, Acevedo, Valeria Silvina, Di Salvo, Emanuel, Gutierrez, Facundo Javier, Madorno, Matias, Mariani, Javier
• Format: Article
• Language: English
• Subjects: Adult; Cannula; Cánula nasal de alto flujo; Diaphragm - diagnostic imaging; Diaphragm - physiology; Diaphragm thickening fraction; Female; Fisiología respiratoria; Fracción de engrosamiento del diafragma; Frecuencia respiratoria; Healthy Volunteers; High flow oxygen therapy; High-flow nasal cannula; High-flow nasal cannula oxygen therapy; Humans; Insufflation - methods; Male; Middle Aged; Oxigenoterapia con cánula nasal de alto flujo; Oxigenoterapia de alto flujo; Oxygen Inhalation Therapy - methods; Prospective Studies; Respiratory physiology; Respiratory rate; Trabajo respiratorio; Work of breathing
• ISSN: 2173-5727; 2173-5727; 1578-6749
• DOI: 10.1016/j.medine.2024.05.017

The primary objective of this study was to evaluate the impact of high-flow nasal cannula oxygen therapy [HFNC] on the diaphragm thickening fraction. Prospective, descriptive, cohort study The study was conducted in the Physiology and Respiratory Care Laboratory, Intensive Care Unit, Hospital Británico de Buenos Aires. Thirteen healthy subjects >18 years old High-flow nasal cannula oxygen therapy Demographic data (age and gender), anthropometric data (weight, height, and body mass index), and clinical and respiratory variables (Diaphragm thickening fraction [DTf], esophageal pressure swing, respiratory rate [RR], esophageal pressure-time product per minute [PTPes/min]). Median DTf decreased significantly as flow increased (p