More about the Viking hypothesis of origin of the Δ32 mutation in the CCR5 gene conferring resistance to HIV-1 infection

The chemokine receptor CCR5 constitutes the major coreceptor for the HIV-1, because a mutant allele of the CCR5 gene named Δ32 was shown to provide to homozygotes a strong resistance against infection. In the present study the frequency of the Δ32 allele was collected in 36 European populations and...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2003-11, Vol.3 (4), p.293-295
Main Authors: Lucotte, Gérard, Dieterlen, Florent
Format: Article
Language:English
Subjects:
Chemokine receptor CCR5
Gene map of allele frequencies in Europe
Δ32 allele
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Summary:The chemokine receptor CCR5 constitutes the major coreceptor for the HIV-1, because a mutant allele of the CCR5 gene named Δ32 was shown to provide to homozygotes a strong resistance against infection. In the present study the frequency of the Δ32 allele was collected in 36 European populations and in Cyprus, and the highest allele frequencies were found in Nordic countries. We constructed an allele map of Δ32 frequencies in Europe; the map is in accordance to the Vikings hypothesis of the origin of the mutation and his dissemination during the eighth to the tenth centuries.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2003.07.001