Human papillomavirus and ovarian cancer (review of literature and meta-analysis)

Many factors are involved in carcinogenesis of the ovary, such human genetic and physiological characteristics as lifestyle, existing diseases of the reproductive system, and, as suggested, the human papillomavirus (HPV). It is well known that the human papillomavirus virus of high carcinogenic risk...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2021-11, Vol.95, p.105086, Article 105086
Main Authors: Ibragimova, M.K., Kokorina, E.V., Tsyganov, M.M., Churuksaeva, O.N., Litviakov, N.V.
Format: Article
Language:English
Subjects:
Female
Human papillomavirus
Humans
Meta-analysis
Ovarian cancer
Ovarian Neoplasms - pathology
Ovarian Neoplasms - virology
Papillomaviridae - physiology
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Prognosis
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Summary:Many factors are involved in carcinogenesis of the ovary, such human genetic and physiological characteristics as lifestyle, existing diseases of the reproductive system, and, as suggested, the human papillomavirus (HPV). It is well known that the human papillomavirus virus of high carcinogenic risk (HCR) plays a crucial role in the onset and development of cervical cancer, as well as cases of HPV positive breast cancer and endometrial cancer. The data on the presence of HPV in ovarian cancer are ambiguous: the researchers claim that there is no complete effect of the virus on the development of this type of cancer, and the detection of HPV in 60–80% of tumors. In this regard, there is a need to systematize the currently available research results on this controversial issue and conduct a meta-analysis of the association of HPV infection with the risk of ovarian cancer. •HPV is found in ovarian cancer in 28.6% of cases, while in the samples of the control group the virus was detected in 8.8%.•Among patients from Europe, the prevalence of HPV in ovarian cancer was 31.2%. Among patients from Asia - 22.5%.•Europeans have a lower relative risk of developing ovarian cancer with HPV infection than Asians (RR 1.87 versus 3.61).
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2021.105086