Sodium borohydride reduction of 4-aryl-N-trifluoroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline ozonide

Reduction of the title ozonide with 1 equiv. of sodium borohydride in ethanol leads to the transformation of the ozonide moiety into d-lactone one, whereas the use of 5 equiv. of the reductant affords the corresponding 1,5-diol, with N-deacylation occurring in all cases.

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Bibliographic Details
Published in:Mendeleev communications 2011-09, Vol.21 (5), p.285-286
Main Authors: Tolstikov, Alexander G., Savchenko, Rimma G., Afon’kina, Svetlana R., Lukina, Elena S., Nedopekin, Denis V., Khalilov, Leonard M., Odinokov, Victor N.
Format: Article
Language:English
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Summary:Reduction of the title ozonide with 1 equiv. of sodium borohydride in ethanol leads to the transformation of the ozonide moiety into d-lactone one, whereas the use of 5 equiv. of the reductant affords the corresponding 1,5-diol, with N-deacylation occurring in all cases.
ISSN:0959-9436
DOI:10.1016/j.mencom.2011.09.019