Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity

[Display omitted] The Buchwald–Hartwig cross-coupling of 5-bromo-4-(furan-2-yl)pyrimidine with various anilines afforded the corresponding new 5-(arylamino)pyrimidines, the reaction being accelerated by microwave irradiation. Most of the obtained compounds proved to possess a high bacteriostatic in...

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Bibliographic Details
Published in:Mendeleev communications 2021-03, Vol.31 (2), p.210-212
Main Authors: Verbitskiy, Egor V., Baskakova, Svetlana A., Belyaev, Danila V., Vakhrusheva, Diana V., Eremeeva, Natalya I., Rusinov, Gennady L., Charushin, Valery N.
Format: Article
Language:English
Subjects:
anti-mycobacterial activity
Buchwald–Hartwig amination
cross-coupling reactions
nitrofurans
pyrimidines
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Summary:[Display omitted] The Buchwald–Hartwig cross-coupling of 5-bromo-4-(furan-2-yl)pyrimidine with various anilines afforded the corresponding new 5-(arylamino)pyrimidines, the reaction being accelerated by microwave irradiation. Most of the obtained compounds proved to possess a high bacteriostatic in vitro effect against Mycobacterium tuberculosis H37Rv, Neisseria gonorrhoeae, and Staphylococcus aureus including Methicillin-resistant strain, which is stronger than that of the commercial drug Spectinomycin.
ISSN:0959-9436
DOI:10.1016/j.mencom.2021.03.021