Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis

[Display omitted] An efficient procedure for the preparation of furo[2,3-c]-quinolin-4(5H)-ones from 2-furoic acid N-(o-bromoaryl)- amides via selective intramolecular C(3)–H arylation of the furan nucleus involves the catalysis by a Pd/NHC system generated in situ from Pd(OAc)2 and readily availabl...

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Bibliographic Details
Published in:Mendeleev communications 2024-03, Vol.34 (2), p.198-200
Main Authors: Shepelenko, Konstantin E., Gnatiuk, Irina G., Minyaev, Mikhail E., Chernyshev, Victor M.
Format: Article
Language:English
Subjects:
arylation
C–H activation
furo[2,3-c]quinolin-4(5H)-ones
N-heterocyclic carbene ligands
palladium
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Summary:[Display omitted] An efficient procedure for the preparation of furo[2,3-c]-quinolin-4(5H)-ones from 2-furoic acid N-(o-bromoaryl)- amides via selective intramolecular C(3)–H arylation of the furan nucleus involves the catalysis by a Pd/NHC system generated in situ from Pd(OAc)2 and readily available IPrSPh HCl proligand. A series of novel furo[2,3-c]quinolin-4(5H)-ones were prepared in 65–80% isolated yields.
ISSN:0959-9436
DOI:10.1016/j.mencom.2024.02.012