Enhanced electrocatalytic reduction activity of Fe-MOF/Pt nanoparticles as a sensitive sensor for ultra-trace determination of Tinidazole

• Published in: Microchemical journal 2022-01, Vol.172, p.106976, Article 106976
• Main Authors: Saeb, Elhameh, Asadpour-Zeynali, Karim
• Format: Article
• Language: English
• Subjects: Differential pulse voltammetry; Electrochemical sensor; Fe-MOF/Pt-GCE; Nanocomposite; Tinidazole
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2021.106976

[Display omitted] •Easy preparation of Fe-MOF/Pt NPs sensor on the glassy carbon electrode.•The Suggested sensor can significantly increase the electrocatalytic activity towards the reduction of tinidazole.•The method is simple, sensitive, and specific, with a short analysis time.•Fe-MOF/Pt NPs/GCE successfully analyzed Tinidazole in various serum, urinary and, tablet samples.•The main advantages of this purpose sensor are easy synthesis method, low limit of detection, and good selectivity, excellent stability, reproducibility, and good repeatability. This paper introduces a novel electrochemical sensor using the metal organic framework and metal nanoparticles (Fe-MOF/Pt NPs) for rapid detection and determination of high sensitivity of Tinidazole (TDZ) using differential pulse voltammetry (DPV) technique. This sensor was synthesized using a simple synthesis method and was first time used to determine TDZ. Firstly, Fe-MOF was synthesized by the chemical method and finally, the platinum nanoparticles (Pt NPs) were deposited on the Fe-MOF/GCE (Fe-MOF/Pt NPs/GCE). The synthesized nanocomposite was detected using Transmission Electron Microscopy (TEM), Brunauer-Emmett-Teller (BET), Raman spectroscopy, Field emission scanning electron microscopy (FESEM), Fourier transforms infrared (FT-IR), X-ray diffraction (XRD), UV–vis spectroscopy, energy-dispersive X-ray spectroscopy (EDX) and element map and electrochemical techniques. The differential pulse voltammetry technique was used under optimum conditions to plot a TDZ reduction calibration graph. Detection limit 43 nM and linear range 0.0196–524.956 μM were calculated for TDZ reduction. The results indicate that the fabricated sensor has good repeatability, reproducibility, and excellent stability in TDZ determination. One of the successes of this sensor is in determining TDZ in tablets and biological samples.