Self-assembly Pt hollow nanospheres for highly selective and ultrasensitive detection of dopamine

• Published in: Microchemical journal 2024-12, Vol.207, p.112023, Article 112023
• Main Authors: Duan, Pengjun, Sun, Qiaomei, Xu, Yihang, Ni, Xiang, Zheng, Jianzhong
• Format: Article
• Language: English
• Subjects: Electrochemical sensing; Neurotransmitter dopamine; Pt hollow nanospheres; Self-assemble
• ISSN: 0026-265X
• DOI: 10.1016/j.microc.2024.112023

[Display omitted] •Pt HNSs were fabricated and used to enhance the sensitivity and selective of biosensor.•Detection of DA with LOD of 0.804 nM.•The fabrication of biosensor platform is designed for real samples detection.•The results reveal the potential mechanism in the sensing interface of self-assembled Pt HNSs. Abnormal concentration of dopamine, one critical neurotransmitter in central nervous system, causes several neurological diseases associated with behavioral responses and brain functions in human beings. Highly sensitive detection of dopamine is of great significance yet challengeable. In this work, Pt hollow nanospheres (Pt HNSs) with a uniform diameter of 30 nm were successfully synthesized in water by self-assembly method under room temperature. The fabricated Pt hollow/Nafion nanospheres modified glassy carbon electrode (Pt HNSs/Nafion/GCE) exhibited superior electrocatalytic performance, with peak currents 2.24 and 4.54 times higher than those of Nafion-modified glassy carbon electrode (Nafion/GCE) and bare glassy carbon electrode (GCE), respectively. Theoretical calculations indicate that dopamine has an adsorption energy of −3.18 eV on the Pt(111) surface, with an electron transfer of + 1.84 |e|, aligning with the 2-electron transfer mechanism. Furthermore, the low energy barrier observed during dopamine oxidation process suggests that the Pt(111) surface is highly favorable for dopamine oxidation. Meanwhile, Pt HNSs/Nafion/GCE electrochemical sensor exhibits highly sensitive and selective response in determination of dopamine ranging from 0.01 to 250 μM with low detection limits of 0.804 nM (S/N = 3). Moreover, the electrochemical sensor shows reliable signals in real test with great anti-interference and stability during the experiments, making it a promising candidate for applications in dopamine sensing.