A new type of ligand derived from N-terminal protected dipeptides in enantioselective addition of phenylacetylene to aromatic ketones at room temperature

A new type of ligand derived from N-terminal protected l-Phe-based dipeptides was found to be effective in catalyzing the enantioselective addition of phenylacetylene to aromatic ketones with up to 91% ee. The reaction required no other metal to promote than Et 2Zn. The whole process was completed a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular catalysis. A, Chemical Chemical, 2006-07, Vol.253 (1), p.86-91
Main Authors: Cai, Hua-qing, Chen, Chao, Liu, Lei, Ni, Jing-man, Wang, Rui
Format: Article
Language:English
Subjects:
Alkynylzinc
Catalysis
Chemistry
Dipeptides
Enantioselective addition
Exact sciences and technology
General and physical chemistry
Ketones
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new type of ligand derived from N-terminal protected l-Phe-based dipeptides was found to be effective in catalyzing the enantioselective addition of phenylacetylene to aromatic ketones with up to 91% ee. The reaction required no other metal to promote than Et 2Zn. The whole process was completed at room temperature and proceeded under very mild reaction conditions. ▪ A new type of ligand derived from N-terminal protected l-Phe-based dipeptides was found to be effective in catalyzing the enantioselective addition of phenylacetylene to aromatic ketones with up to 91% ee. The reaction required no other metal to promote than Et 2Zn. The whole process was completed at room temperature and proceeded under very mild reaction conditions.
ISSN:1381-1169
1873-314X
DOI:10.1016/j.molcata.2006.03.009