Palladium/1,2-bis(diphenylphosphino) ethane catalysed amination of aryl halides with aliphatic/aromatic amines

• Published in: Journal of molecular catalysis. A, Chemical Chemical, 2006-11, Vol.259 (1), p.46-50
• Main Authors: Bhanushali, Mayur J., Nandurkar, Nitin S., Bhor, Malhari D., Bhanage, Bhalchandra M.
• Format: Article
• Language: English
• Subjects: Amines; Aryl halides; Catalysis; Chemistry; Exact sciences and technology; General and physical chemistry; Homogeneous catalyst; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Ullmann coupling
• ISSN: 1381-1169; 1873-314X
• DOI: 10.1016/j.molcata.2006.06.014

The Ullmann coupling of amines with aryl iodide and bromides has been carried out efficiently using Pd(OAc) 2/1,2-bis(diphenylphosphino) ethane [DPPE] in toluene as a solvent. The effects of various parameters such as temperature, solvent, base, catalyst loading and metal–ligand ratio on the reaction system were studied. The reaction is applicable to a wide variety of substituted aryl amines and alkyl amines with different steric and electronic properties. ▪ The Ullmann coupling of amines with aryl iodide and bromides has been carried out efficiently using Pd(OAc) 2/1,2-bis(diphenylphosphino) ethane [DPPE] in toluene as a solvent. The effects of various parameters such as temperature, solvent, base, catalyst loading and metal–ligand ratio on the reaction system were studied. The reaction is applicable to a wide variety of substituted aryl amines and alkyl amines with different steric and electronic properties.