Volumetric, acoustical and viscometric behavior of glycine and DL-alanine in aqueous furosemide solutions at different temperatures

• Published in: Journal of molecular liquids 2015-12, Vol.212, p.656-664
• Main Authors: Chauhan, Suvarcha, Pathania, Lalita, Sharma, Kundan, Kumar, G.
• Format: Article
• Language: English
• Subjects: Density; DL-alanine; Furosemide; Glycine; Speed of sound; Viscosity
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2015.09.042

Drug (furosemide)–amino acid (glycine and DL-alanine) interactions have been investigated in aqueous medium from density (ρ), speed of sound (u) and viscosity (η) studies. The density and speed of sound data has been employed to obtain partial molar volume(Vϕo), partial molar volume of transfer(ΔtrVϕo), partial molar expansion coefficient∂Vϕo∂Tp, second derivative∂2Vϕo∂T2p, isentropic compressibility(κs), partial molar isentropic compressibility (κϕ,so) and partial molar isentropic compressibility of transfer(Δtrκϕ,so). The viscosity data have been used to calculate the viscosity B-coefficients, its temperature derivative dB/dT, viscosity B-coefficient of transfer (ΔtrB) and various thermodynamic parameters of activation of viscous flow for amino acids in furosemide solutions. A detailed insight into the physicochemical interactions e.g. ionic–hydrophilic, hydrophilic–hydrophilic and hydrophilic–hydrophobic interactions in the amino acid-drug system along with the structure-making/structure-breaking tendency of amino acids have been retrieved through the perusal of these calculated parameters. [Display omitted] •Physicochemical properties of glycine and DL-alanine in aqueous solutions of furosemide have been investigated.•Temperature dependence of calculated thermophysical parameters has been discussed.•Ionic–hydrophilic/hydrophilic–hydrophilic amino acid-furosemide interactions are dominant.•Both glycine and DL-alanine behave as structure makers in furosemide solution.