Temperature dependent physicochemical investigations of some nucleic acid bases (uracil, thymine and adenine) in aqueous inositol solutions

• Published in: Journal of molecular liquids 2021-03, Vol.326, p.115210, Article 115210
• Main Authors: Rajput, Poonam, Richu, Sharma, Taniya, Kumar, Ashwani
• Format: Article
• Language: English
• Subjects: Apparent molar properties; Hydration number; Nucleic acid bases; Viscosity B-coefficients
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2020.115210

Physicochemical studies have been carried out of some nucleic acid bases (uracil, thymine and adenine) in aqueous and mixed aqueous inositol (0.1, 0.2 and 0.3 mol kg −1) solutions at six different temperatures (293.15, 298.15, 303.15, 308.15, 313.15, 318.15) K. By means of density, speed of sound and viscosity values, various volumetric, compressibility and viscometric parameters like apparent molar properties (Vϕ, Kϕ,s), limiting apparent molar properties (V0ϕ, K0ϕ,s), transfer properties (∆trV0ϕ, ∆trK0ϕ,s and ∆trB), hydration number (nH) etc. were computed. By using Jones-Dole equation, viscosities B-coefficients have been calculated. Solvation behavior of above mentioned nucleic acid bases in aqueous solutions of inositol has also been evaluated. Using cosphere overlap model, various intermolecular interactions prevailing in the ternary systems have been discussed. By making use of the temperature derivative of B coefficient (dB/dT), the structure making/breaking of solute have been investigated. •Physicochemical properties are investigated for uracil, thymine and adenine in aqueous inositol solutions.•VAB and KAB values suggested pairwise interactions between nucleic acid bases and inositol systems.•Results indicated dominance of hydrophilic-hydrophilic interactions over hydrophobic interactions.•(dB/dT) values revealed the structure breaking behavior for nucleic acid bases in aqueous inositol solutions.