Synthesis, characterization, spectroscopic properties and DFT study of a new pyridazinone family

• Published in: Journal of molecular structure 2017-11, Vol.1148, p.162-169
• Main Authors: Arrue, Lily, Rey, Marina, Rubilar-Hernandez, Carlos, Correa, Sebastian, Molins, Elies, Norambuena, Lorena, Zarate, Ximena, Schott, Eduardo
• Format: Article
• Language: English
• Subjects: Characterization; DFT; Pyridazinone; Synthesis
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2017.06.004

Nitrogen compounds are widely investigated due to their pharmacological properties such as antihypertensive, antinociceptive, antibacterial, antifungal, analgesic, anticancer and inhibition activities and lately even as pesticide. In this context, we present the synthesis of new compounds: (E)-6-(3,4-dimethoxyphenyl)-3-(3-(3,4-dimethoxyphenyl)acryloyl)-1-(4-R-phenyl)- 5,6-dihydropyridazin-4(1H)-one (with R = H(1), -Cl(2), -Br(3), I(4) and COOH(5)) that was carried out by reaction of (1E, 6E)-1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione with a substituted phenylamine with general formula p-R-C6H4NH2 (R = H (1), Cl (2), -Br(3), I(4) and COOH(5)). This is the first synthesis report of a pyridazinone using as precursors a curcuminoid derivative and a diazonium salt formed in situ. All compounds were characterized by EA, FT-IR, UV–Vis, Emission,1H- and13C-NMR spectroscopy and the crystalline and molecular structure of 4 was solved by X-rays diffraction method. DFT and TD-DFT quantum chemical calculations were also employed to characterize the compounds and provide a rational explanation to the spectroscopic properties. To assess the biological activity of the systems, we focused on pesticide tests on compound 2, which showed an inhibitory effect in plant growth of Agrostis tenuis Higland. [Display omitted] •Synthesis of a family of five pyridazinone dyes.•XRay diffraction.•bioactivity effect of compound 2 was evaluated.•DFT study of pyridazinone dyes.