Synthesis, spectral, in vitro microbial and DNA cleavage studies of isatin bishydrozone metal complexes

• Published in: Journal of molecular structure 2023-04, Vol.1277, p.134837, Article 134837
• Main Authors: Sail, Bhushan S., Naik, Vinod H., Kamli, Majid Rasool, Prasanna, B. M.
• Format: Article
• Language: English
• Subjects: Antimicrobial; DNA; Electrochemical; Spectroscopic; Transition metal complexes
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2022.134837

•By coordinating with metal ions through azomethine nitrogen and Lactonyl oxygen atom, the newly synthesized Schiff bases act as tetradentate ligands.•The electrochemical properties of the Cu(II) and Co(II) metal complexes, investigated in DMSO exhibited the significant one electron quasi-reversible electron transfer process.•The Schiff bases and their metal complexes were found to be highly active against some of the antibacterial and antifungal species. On coordination, there is a huge rise in activity.•The complexes displayed non-specific DNA cleavage, according to research on DNA cleavage. Combining all of these findings, we suggest the structure shown below (Fig. 6). ONNO donor Schiff bases with recent group of Co(II), Ni(II), and Cu(II) complexes have been created and analyzed using spectroscopic research, thermal analysis, magnetic susceptibility, conductance tests, and elemental analysis. Via lactonyl oxygen and azomethine nitrogen, the Schiff bases are coordinated to the metal ion. In most common organic solvents, the complexes are insoluble but soluble in DMSO. The Co(II), Ni(II), and Cu(II) complexes' antibacterial properties, tested on quartet bacteria and two fungi strains showed an increased activity with respect to the Schiff bases. The Co(II), Ni(II) and Cu(II) complexes show more pronounced DNA cleaving activity. On cyclic voltammograms, the Cu(II) or Co(II) complexes tested in the DMSO solution showed metal-centered electro activity between 1.5 and +1.5 V. [Display omitted]