An efficient, catalyst-free synthesis of novel indenoquinoxaline fused hydrazinylthiazoles and their antimicrobial evaluation with molecular docking study

• Published in: Journal of molecular structure 2025-02, Vol.1321, p.140069, Article 140069
• Main Authors: Sawant, Shivaji, Patil, Pradeep, Salunke, Govind, Kamble, Rupali, Bharmal, Mayur, Sankpal, Sandeep, Sonawane, Kailas, Hangirgekar, Shankar
• Format: Article
• Language: English
• Subjects: Antimicrobial activity; Catalyst free; Indenoquinoxaline fused hydrazinyl thiazole; Molecular docking; One-pot reaction
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.140069

•Synthesis of new Indenoquinoxaline fused hydrazinyl thiazole derivatives.•Catalyst free synthesis at room temperature condition.•Use of alcohol as a green reaction medium.•Antimicrobial activity against S. aureus and P. aeruginosa•Good Interaction of Indenoquinoxaline- hydrazinyl thiazoles with DHFR & DNA gyrase. An efficient catalyst-free synthesis of Indenoquinoxaline fused hydrazinyl thiazoles through a one-pot reaction of 11-H-indeno[1,2-b]quinoxalin-11-ones, substituted phenacyl bromide and thiosemicarbazide at room temperature in ethanol is disclosed for the first time. All indenoquinoxaline fused hydrazinyl thiazoles were obtained in excellent yields within a shorter reaction time. The structure of synthesized indenoquinoxaline fused hydrazinyl thiazoles are supported by FT-IR, 1H NMR spectroscopy, and mass analysis. The synthesized indenoquinoxaline fused hydrazinyl thiazoles were screened for antimicrobial activity against the Gram-positive S. aureus and Gram-negative P. aeruginosa and further supported by molecular docking study, which will provide new ideas to design novel inhibitors. [Display omitted]