Metal organic framework-modified bioadaptable implant potentiates the reconstruction of nerve microenvironment via immunometabolism reprogramming

Whereas immune homeostasis and metabolic reprogramming are recognized as fundamental players in the restoration of posttraumatic nerve microenvironment, much less is known about the role of immunometabolism in this progress. In nerve tissue, the immune identity of resident macrophages contributes to...

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Bibliographic Details
Published in:Nano today 2023-04, Vol.49, p.101814, Article 101814
Main Authors: Yao, Xiangyun, Yan, Zhiwen, Liu, Anqi, Zhan, Lei, Liu, Yanan, Huang, Chen, Ouyang, Yuanming, Ruan, Hongjiang, Qian, Yun, Fan, Cunyi
Format: Article
Language:English
Subjects:
Immunometabolism reprogramming
Macrophage polarization
Metal organic framework
Nerve microenvironment
Nerve regeneration
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Summary:Whereas immune homeostasis and metabolic reprogramming are recognized as fundamental players in the restoration of posttraumatic nerve microenvironment, much less is known about the role of immunometabolism in this progress. In nerve tissue, the immune identity of resident macrophages contributes to the reshaping of metabolic states. In turn, rapid metabolic shifts and on-demand energy production are also needed to support versatile macrophage functions. Here, we develop a self-powered nerve bridging scaffold by integrating metal organic frameworks (MOFs) and reduced graphene oxide (rGO) nanoparticles into polycaprolactone (PCL) substrates. This provides a bioadaptable neural interface to enable the improved oxidative metabolism in injured nerves and phenotypic switch of infiltrated macrophages. The unique molecular identity of reprogrammed macrophages is also identified, with macrophages displaying enhanced oxidative phosphorylation, mitochondrial bioenergetics and suppressed calcium signaling. Thus, our piezoelectric scaffolds have matched bioadaptability with nerve immunometabolism and facilitate nerve repair. [Display omitted] •Piezoelectric rGO@MOF/PCL scaffolds triggered nerve immunometabolism reprogramming.•Macrophage phenotypic switches were modulated by VGCC and KATP channels.•Improved oxidative metabolism and decreased glycolysis were seen in macrophages.•Ca2+ influx and Ca2+-CaMKII-NF-κB axis in cells were suppressed by piezoelectric scaffolds.
ISSN:1748-0132
1878-044X
DOI:10.1016/j.nantod.2023.101814