Chronic microinjection of valproic acid into the nucleus accumbens attenuates amphetamine-induced locomotor activity

Amphetamine (AMPH)-induced hyper-locomotion has been well manifested in an animal model of psychiatric diseases such as drug addiction and bipolar disorder. In this study, we investigated the effects on AMPH-induced locomotor activity of chronically microinjected valproic acid into the nucleus accum...

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Bibliographic Details
Published in:Neuroscience letters 2008-02, Vol.432 (1), p.54-57
Main Authors: Kim, Wha Young, Kim, Seungwoo, Kim, Jeong-Hoon
Format: Article
Language:English
Subjects:
Amphetamine
Amphetamine - toxicity
Animals
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Central Nervous System Stimulants - toxicity
Disease Models, Animal
Drug Interactions
Fundamental and applied biological sciences. Psychology
Hyperkinesis - chemically induced
Hyperkinesis - drug therapy
Hyperkinesis - physiopathology
Locomotor activity
Male
Medical sciences
Microinjection
Microinjections
Motor Activity - drug effects
Neuropharmacology
Nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - physiopathology
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Valproic acid
Valproic Acid - pharmacology
Vertebrates: nervous system and sense organs
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Summary:Amphetamine (AMPH)-induced hyper-locomotion has been well manifested in an animal model of psychiatric diseases such as drug addiction and bipolar disorder. In this study, we investigated the effects on AMPH-induced locomotor activity of chronically microinjected valproic acid into the nucleus accumbens (NAcc). Rats with guide cannular implanted bilaterally were divided into three groups and either saline or valproic acid (100 or 300 μg/0.5 μl/side) was microinjected into the NAcc once daily for 7 days. On day 8, half of each group received either saline or AMPH (1 mg/kg, i.p.), respectively, and locomotor activity was measured for 2 h. The increases of both horizontal locomotion and rearing by AMPH were attenuated in the rat pre-treated with valproic acid compared to saline in a dose-dependent manner. These results indicate that neuronal modifications in the NAcc induced by chronic valproic acid can modulate amphetamine-induced locomotor activity.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2007.12.005