Sickle cell disease in pregnancy

Abstract With advances in management, the majority of women in the UK with sickle cell disease now survive to have children. The high risk of fetal and maternal sequelae in their pregnancies mandates multidisciplinary management involving an obstetrician, a haematologist, an anaesthetist and a haemo...

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Bibliographic Details
Published in:Obstetrics, gynaecology and reproductive medicine gynaecology and reproductive medicine, 2008-10, Vol.18 (10), p.272-278
Main Authors: Oteng-Ntim, Eugene, Chase, Apryll R, Howard, Jo, Khazaezadeh, Nina, Anionwu, Elizabeth N
Format: Article
Language:English
Subjects:
clinical presentation
management
Obstetrics and Gynecology
pathophysiology
pregnancy
sickle cell disease
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Summary:Abstract With advances in management, the majority of women in the UK with sickle cell disease now survive to have children. The high risk of fetal and maternal sequelae in their pregnancies mandates multidisciplinary management involving an obstetrician, a haematologist, an anaesthetist and a haemoglobinopathy specialist nurse. Hydroxycarbamide, a new treatment for sickle cell disease, is contraindicated in pregnancy. Exchange transfusion may be indicated in women with serious obstetric or haematological complications. In those with sickle cell disease, the entire pregnancy is a high-risk period that warrants close monitoring. It is thus important for every obstetrician to be familiar with the condition.
ISSN:1751-7214
1879-3622
DOI:10.1016/j.ogrm.2008.08.001