PROGNOSTIC VALUE OF CRTC1-MAML2 TRANSLOCATION IN SALIVARY MUCOEPIDERMOID CARCINOMA: SYSTEMATIC REVIEW AND META-ANALYSIS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-09, Vol.130 (3), p.e243-e244
• Main Authors: PÉREZ-DE-OLIVEIRA, MARIA EDUARDA, WAGNER, VIVIAN PETERSEN, ARAÚJO, ANNA LUíZA DAMACENO, MARTINS, MANOELA DOMINGUES, SANTOS-SILVA, ALAN ROGER, BINGLE, LYNNE, VARGAS, PABLO AGUSTIN
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.629

Objectives: The presence of the CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma (MEC) has been associated with a favorable clinical outcome. However, the real prognostic value of the translocation has been debated due to recent controversial findings. The aim of the present study was to perform a systematic review to try to understand the prognostic potential of the CRTC1-MAML2 translocation in MEC. Study Design: An electronic search was carried out using the MEDLINE/PubMed, Embase, and Scopus databases to retrieve articles that assessed the correlation between CRTC1-MAML2 translocation and survival of patients diagnosed with MEC. The presence of the translocation was correlated to clinicopathological parameters and survival rates. Qualitative and quantitative synthesis was done to determine the usefulness of the translocation as a prognostic factor. Results: A total of 10 published articles were included in the qualitative synthesis. The prevalence of the translocation varied from 33.7% to 69.7%. Seven studies observed a significant association between the presence of the CRTC1-MAML2 translocation and survival rates, which could improve disease-free, disease-specific, and/or overall survival. Conclusions: The detection of the CRTC1-MAML2 translocation appears to be a prognostic marker in MEC. However, important limitations were found in the published studies.