ANTIVIRAL ACTIVITY OF RED PROPOLIS IN HERPEVIRUSES THAT CAUSES PERIBUCCAL AND INTRAORAL LESIONS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2020-09, Vol.130 (3), p.e259-e260
• Main Authors: LEMOS, LETICIA, MAIA, IVONILDA DE ARAúJO MENDONçA, MAIA, MARIANA MENDONçA, BRUM, EVANISA HELENA MAIO DE, FERREIRA, SôNIA MARIA SOARES
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.691

About two-thirds of the world’s population has the herpes simplex virus 1 (HSV1) and 2 (HSV2). The lesions are highly contagious and can cause abortions, congenital malformations, and death in those who are immunosuppressed. Conventional treatment has numerous side effects; in addition, there is increased resistance to current antiviral drugs. Therefore, the development of new antiviral drugs with lower cytotoxicity is relevant. In this context, the antiviral activity of red propolis stands out. Objective: To conduct a systematic review of the literature on the antiviral activity of red propolis in herpesviruses. Study Design: Systematic literature review based on scientific articles obtained in PubMed, SciELO, and ScienceDirect between February 19, 2019 to March 21, 2019. Results: Twenty-three articles on the subject were found. In tests involving HSV1 and HSV2, Yildirim et al. (2016) found that the replication capability of HSV1 and HVS2 was significantly suppressed at 25, 50, and 100 μg/mL of propolis. Simoni et al. (2018) observed significant antiviral activity against 3 species of herpesvirus. Münstedt (2019) concluded that the antiviral effect of propolis was superior to acyclovir. Conclusion: There are consistent results for the therapeutic use of red propolis against herpesviruses. However, more research on the antiviral activity of red propolis is necessary, besides in vivo assays.