Loading…
WOUND HEALING ACTIVITY OF A GELATIN-BASED HYDROGEL CONTAINING 2% ETHANOLIC EXTRACT OF HIMATANTHUS BRACTEATUS
To analyze the effect of topical application of a photopolymerizable hydrogel based on methacrylated gelatin containing 2% ethanolic extract of Himatanthus bracteatus (GelMA-HB) on wound healing in rodents. Standard-sized (0.8 cm diameter) round-shaped wounds were made in the back of Wistar rats tre...
Saved in:
Published in: | Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2022-09, Vol.134 (3), p.e225-e225 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | To analyze the effect of topical application of a photopolymerizable hydrogel based on methacrylated gelatin containing 2% ethanolic extract of Himatanthus bracteatus (GelMA-HB) on wound healing in rodents.
Standard-sized (0.8 cm diameter) round-shaped wounds were made in the back of Wistar rats treated with photopolymerizable hydrogel based on methacrylated gelatin (GelMA), GelMA-HB, and saline (CTR). The animals were euthanized after 3, 7, and 14 days. Wound retraction index (WRi), wound healing histologic grading (WHHG), and immunohistochemical expression of α-SMA and CD105 were assessed for myofibroblastic differentiation (MFd) and microvascular density (MVd) analysis, respectively.
The WRi and WHHG in GelMA-HB were significantly greater than in GelMA (P < .05) and CTR (P < .01) over the full time course of the experiment. Both the MFd and MVd were greater in GelMA-HB than in CTR on day 3 (P < .05) and day 7 (P < .001).
The GelMA-based formulation containing ethanolic extract of H. bracteatus improved wound healing in a rodent model, and such biological effects might be related to the modulation of myofibroblastic and microvascular differentiation over the course of wound healing. |
---|---|
ISSN: | 2212-4403 2212-4411 |
DOI: | 10.1016/j.oooo.2022.01.713 |