SYSTEMATIC REVIEW OF ORAL AND MAXILLOFACIAL HISTOPLASMOSIS - PRELIMINARY RESULTS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2022-09, Vol.134 (3), p.e235-e235
• Main Authors: Stelter, Grazielle Oliveira, Schmidt, Tuany Rafaeli, De Oliveira Zigmundo, Gisele Correa, Zettermann, Paula Heck, Schuch, Lauren Frenzel, Silveira, Felipe Martins, Martins, Manoela Domingues
• Format: Article
• Language: English
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2022.01.754

The objective was to analyze the available data regarding oral and maxillofacial histoplasmosis (OMH) into a systematic review to integrate the demographic, clinical, and histopathologic features and diagnosis, treatment, recurrence, and survival of this condition. An electronic search without publication date or language restriction was undertaken in November 2020 in the following databases: Medline/PubMed, Web of Science, Scopus, and Embase. The eligibility criteria were restricted to case reports and case series. A descriptive analysis was performed. One hundred nine articles met the eligibility criteria, yielding 126 cases of OMH. Men (77.8%) were more affected, with a mean age of 50.7 years (SD ± 16.3). In relation to the anatomic site, 54 (42.9%) lesions were found in the tongue, with ulcers (81.7%) being the main fundamental lesion. Most lesions were symptomatic (58.7%) with a unique clinical presentation (57.9%). Oral biopsy was performed in 100% of cases. Regarding laboratory investigations, the anti-HIV test was the most requested exam. Amphotericin B (43.7%) was the treatment choice in the majority of cases. The mean follow-up was 44.8 weeks (SD ± 40). The present systematic review provides information that could be helpful to clinicians for the diagnosis and management of this condition.