Anti-inflammatory glycosides from Gomphandra mollis Merr.: Structural elucidation and mechanistic insights

Eight previously unreported glycosides, designated gomphandranosides I–VIII, along with nine known compounds, were isolated from the roots of Gomphandra mollis Merr. Their structures were elucidated through comprehensive spectroscopic analyses, including NMR, HR-ESI-MS, CD, DP4+ probability, and ECD...

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Published in:Phytochemistry (Oxford) 2025-11, Vol.239, p.114583, Article 114583
Main Authors: Tran Huynh, Quoc-Dung, Thi Phan, Thuy-Tien, Chu, Man-Hsiu, Nguyen, Thanh-Vu, Thi Duong, Truc-Ly, Hsu, Su-Jung, Wang, Yun-Han, Pham, Ngoc-Thac, Nguyen Bui, Bien-Thuy, Nguyen, Dang-Khoa, Vo, Thanh-Hoa, Liu, Ta-Wei, Lee, Ching-Kuo
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Gomphandra mollis
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Mice
Molecular docking
Molecular Docking Simulation
Molecular Structure
Network pharmacology
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Plant Roots - chemistry
RAW 264.7 Cells
Stemonuraceae
Structure-Activity Relationship
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