The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent

Abstract Exposure to overnutrition in utero may increase offspring cardiometabolic disease risk. A mouse model of maternal exposure to an obesogenic diet (DIO) was used to determine effects on fetal and placental weight and gene expression in mid- and late gestation. DIO altered placental gene expre...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2013-11, Vol.34 (11), p.1087-1090
Main Authors: King, V, Hibbert, N, Seckl, J.R, Norman, J.E, Drake, A.J
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Birth Weight
Diet, High-Fat - adverse effects
Dietary Sucrose - adverse effects
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Development
Fetal growth
Fetal Weight
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Internal Medicine
Male
Maternal Nutritional Physiological Phenomena
Mice
Mice, Inbred C57BL
Obesity
Obesity - etiology
Obstetrics and Gynecology
Overnutrition - metabolism
Placenta
Placenta - metabolism
Placentation
Pregnancy
Pregnancy Proteins - biosynthesis
Pregnancy Proteins - genetics
Pregnancy Proteins - metabolism
RNA, Messenger - metabolism
Sex Characteristics
Weight Gain
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Summary:Abstract Exposure to overnutrition in utero may increase offspring cardiometabolic disease risk. A mouse model of maternal exposure to an obesogenic diet (DIO) was used to determine effects on fetal and placental weight and gene expression in mid- and late gestation. DIO altered placental gene expression in mid-gestation without differences in fetal or placental weights. Weight gain was attenuated in DIO dams in late gestation and male pup weight was reduced, however there were no persistent changes in placental gene expression. Differences in maternal weight gain and/or specific dietary components may impact on fetal and placental growth and later disease risk.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2013.09.006