Speciation study and biological activity of copper (II) complexes with picolinic and 6-methylpicolinic acid with different components of blood serum of low molecular mass in KNO3 1.0 mol·L−1 at 25 °C

• Published in: Polyhedron 2022-01, Vol.211, p.115562, Article 115562
• Main Authors: Del Carpio, Edgar, Serrano, María L., Hernández, Lino, Madden, Waleska, Lubes, Vito, Landaeta, Vanessa R., Rodríguez-Lugo, Rafael E., Lubes, Giuseppe, Stern, Anita, Ciangherotti, Carlos, Jiménez, Lissette
• Format: Article
• Language: English
• Subjects: Chemical equilibrium; Chemical speciation; Copper; Molecular docking; Oxidative stress; Super oxide radical
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2021.115562

In this article its presented the chemical speciation studies of Copper(II) complexes with pyridinecarboxylic acids and different components of low molecular mass blood plasma. Additionally it was studied, the antioxidant activity of the complexes and their protective effect at the cellular level and the receptor ligand interaction through Molecular Docking. [Display omitted] •There is a predilection towards the formation of ternary complexes in solution.•The Cu(Pic)2 complex has a planal square structure with a trans geometry.•The complexes exhibit antioxidant activity which is concentration dependent.•The metallic center is essential for the biological activity. In the present work, the chemical speciation of ternary complexes of copper (II) with picolinic acid and 6-methylpicolinic acid and different ligands, such as, components of the blood plasma of low molecular mass (lactic acid, oxalic acid, citric acid, and phosphoric acid) were studied by measurements of emf(H) in KNO3 1.00 mol·L−1. Potentiometric studies showed a predilection towards the formation of ternary species in solution, except for the copper (II)-picolinate-phosphate systems. The biological activity of the binary and ternary complexes isolated in situ, against reactive oxygen species was studied showing a concentration-dependent effect due to a possible mechanism of electron transfer. Finally, for the complexes Cu(Pic)2 and for the ligands were studied the ligand-receptor interaction on a PI3k of human origin by molecular docking, showing that, by themselves, the ligands are not capable of interacting with the active site of the enzyme. The metallic center is fundamental to generate reversible electrostatic interactions, that can be key to the indirect hypoglycemic effect exhibited by the Cu(Pic)2 complex reported in the literature.