99-POS

• Published in: Pregnancy hypertension 2015-01, Vol.5 (1), p.54-54
• Main Authors: Pramithapuri, Tythania, Aldika Akbar, Muhammad Ilham, Susanna, Maurin, Joewono, Hermanto Tri, Aditiawarman, Aditiawarman, Sulistyono, Agus, Dachlan, Erry G
• Format: Article
• Language: English
• Subjects: Cardiovascular; Obstetrics and Gynecology
• ISSN: 2210-7789
• DOI: 10.1016/j.preghy.2014.10.105

Objectives To describe characteristics of pregnancies in SLE and in those with flares to evaluate factors increasing the risk of preeclampsia and prematurity. Methods We conducted a retrospective study of pregnancies complicated by SLE at Dr.Soetomo teaching hospital from 2009 to 2013, to assess the SLE impact on pregnancy outcome. Total pregnancies with SLE were 66 cases (63 patients) with prevalence 0.51%. The mean age of patients with previous SLE was 28.4 years old, with approximately 5.13 years of duration. 37 cases (56.06%) were diagnosed during pregnancy and 28 cases (42.4%) were still active 6 months preconception. Results There were 15 (22.73%) preeclampsia, 6 (9.09%) PPROM, 3 (4.54%) antiphospholipid syndrome, 1 (1.52%) gestational diabetes, and 29 cases with flare-up (43.9%). Most flares occurred in second and third trimester, respectively, 12 (41.4%) and 10 (34.55%) cases. The manifestations of flares were 16 (59.3%) nephritis, 14 (51.8%) hematology disorder and nine (33.3%) serositis. We found significant associations among SLE flare-up with SLEDAI score 8.34 ± 3.59, hypertension, leucopeni, hypoalbuminemia, increased ureum and creatinine, proteinuria, hematuria and urinary granular cast ( p < 0.05). Associations also appeared among preeclampsia with flare, hypoalbuminemia, hematuria and granular cast ( p < 0.05). Impacts on fetal side were 25 (37.8%) premature deliveries, 6 (9.1%) miscarriages and only 24 (36.4%) cases delivered at term successfully. Our study revealed association among prematurity with antenatal care (nonbooked-case), active condition within 6 months preconception and hematuria ( p < 0.05). Statistically significant result of variables related to preeclampsia, prematurity and flare-up can be seen in table below. Conclusions Preeclampsia, prematurity and flares appeared to increase when lupus women become pregnant. Odds Ratio for Flares, Preeclampsia and Prematurity (respectively) Nonbooked-case – – 4.84 Preconceptionally active – – 4.29 Flare – 5.1 – Hypertension 5.1 – – Leucopeni 3 – – Hypoalbuminemia 4.7 10.98 – Increased ureum/creatinine 3.9/3.4 – – Proteinuria 6.6 – – Hematuria 3.5 17.2 4.7 Granular-cast 4.8 5.7 – Disclosures T. Pramithapuri: None. M.A. Akbar: None. M. Susanna: None. H.T. Joewono: None. A. Aditiawarman: None. A. Sulistyono: None. E.G. Dachlan: None.