Sleep changes during a spontaneous manic episode: PSG assessment in a clinical context

•PSG is a reliable and safe tool that allows the precise quantification of night rest and to evaluate its architecture.•Changes in sleep architecture appear to be sensitive markers of clinical changes during a manic episode of bipolar disorder.•Sleep management during the manic episode is confirmed...

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Bibliographic Details
Published in:Psychiatry research 2023-05, Vol.323, p.115136, Article 115136
Main Authors: Pacchioni, F, Cavallini, M.C., Fregna, L., Casoni, F., Sarzetto, A., Attanasio, F., Barbini, B., Locatelli, M., Colombo, C
Format: Article
Language:English
Subjects:
Bipolar disorder
Bipolar Disorder - diagnosis
Female
Humans
Male
Mania
Mood Disorders - complications
PSG
REM
Sleep
Sleep, REM
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Summary:•PSG is a reliable and safe tool that allows the precise quantification of night rest and to evaluate its architecture.•Changes in sleep architecture appear to be sensitive markers of clinical changes during a manic episode of bipolar disorder.•Sleep management during the manic episode is confirmed as a primary clinical objective. Sleep plays a key role in the pathogenesis and clinical presentation of mood disorders. However, only a few studies have investigated sleep architecture during the manic episodes of Bipolar Disorder (BD) and changes in sleep parameters that follow clinical variations. Twenty-one patients (8 males, 13 females) affected by BD, manic phase, underwent polysomnographic recordings (PSG) at the beginning of the admission in our ward (T0) and after three weeks of hospital treatment (T1). All participants were clinically evaluated using Young Mania Rating Scale (YMRS), Pittsburgh Sleep Quality Index (PSQI) and Morningness-Eveningness Questionnaire (MEQ). During the admission, we observed an increase in both quantity (Total Sleep Time - TST) and quality (Sleep Efficiency - SE) of sleep. In addition, clinical improvement, evaluated with YMRS and PSQI scales, was accompanied by a significant increase in the percentage of REM sleep. According to our findings, the improvement of manic symptoms is accompanied by an increase in "REM pressure" (increase in REM% and REM density, reduction of REM latency). Overall, changes in sleep architecture appear to be markers sensitive to clinical variations during manic phases of Bipolar Disorder.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2023.115136