Investigation on the influence of dose minimisation management on the PET image quality

• Published in: Radiography (London, England. 1995) England. 1995), 2014-02, Vol.20 (1), p.65-69
• Main Authors: Hishar, H, Fathinul Fikri, A.S, Salasiah, M, Noramaliza Mohd, N, Abdul Jalil, N
• Format: Article
• Language: English
• Subjects: 18F-FDG; Administered dose/body weight (kg); COV; PET image quality; Radiology
• ISSN: 1078-8174; 1532-2831
• DOI: 10.1016/j.radi.2013.10.005

Abstract The issue of balancing patient's dose radiation and image quality improvement possesses an interesting argument in PET/CT practices where newer technologies evolved one after another and increased demands from referring physicians. Therefore, this study aims to demonstrate that a reasonable-to-excellent PET image could be achieved via implementation of low dose of18 F-FDG/kg administered. A total number of 50 patients (34 men, 16 women, age 53.8 ± 14.05 years) who were injected with an activity ranging from 4.19 to 7.98 MBq/kg (5.80 ± 0.90 MBq/kg) of18 F-FDG for PET/CT whole body examination were evaluated retrospectively. Image quality was scored visually by two nuclear radiologists using a three-point scoring scale (poor, reasonable and excellent). COV values measured in a right lobe of liver (ROI: 2–5 cm3 ) were recorded and calculated as a parameter reflecting noise. The prediction of the PET image quality adopting18 F-FDG dose of 6 MBq/kg, was significant ( p  6 MBq/kg, higher noise were observed with COV averaged of 27.4% whereas COV averaged of 25.7% were observed for dose at