Late toxicity after postprostatectomy salvage radiation therapy

Abstract Purpose To evaluate late toxicity in patients who received salvage external beam radiotherapy (EBRT) for a detectable prostate-specific antigen (PSA) level after radical prostatectomy (RP). Methods A cohort of 308 consecutive patients underwent salvage EBRT from July 1987 through June 2003...

Full description

Saved in:
Bibliographic Details
Published in:Radiotherapy and oncology 2009-11, Vol.93 (2), p.203-206
Main Authors: Peterson, Jennifer L, Buskirk, Steven J, Heckman, Michael G, Crook, Julia E, Ko, Stephen J, Wehle, Michael J, Igel, Todd C, Prussak, Karin A, Pisansky, Thomas M
Format: Article
Language:English
Subjects:
Adjuvant therapy
Adult
Aged
Aged, 80 and over
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prostate-specific antigen
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms - surgery
Radiotherapy
Radiotherapy - adverse effects
Radiotherapy Dosage
Retrospective Studies
Salvage Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose To evaluate late toxicity in patients who received salvage external beam radiotherapy (EBRT) for a detectable prostate-specific antigen (PSA) level after radical prostatectomy (RP). Methods A cohort of 308 consecutive patients underwent salvage EBRT from July 1987 through June 2003 for a detectable PSA level after RP. All were treated with high-energy photons (6–20 MV) to a median dose of 64.8 Gy (range: 54.0–72.4 Gy) in 1.8- to 2.0-Gy fractions. Results Median follow-up from the completion of EBRT was 60 months (range: 1 day–174 months). Late toxicity occurring more than 90 days after EBRT completion was identified in 41 patients (13%). Twelve patients (3.9%) had grade 2 urethral strictures and were treated with urethral dilation, 3 patients had grade 3 cystitis, and 1 had a grade 4 rectal complication. These numbers correspond to an estimated 0.7% (95% confidence interval, 0.0–1.6%) of patients experiencing a grade 3 or 4 complication by 5 years after the start of EBRT. Conclusions Salvage EBRT for a detectable PSA level after RP is the only curative treatment in this setting. This treatment can be administered in a manner that results in a low likelihood of late complications.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2009.08.035