Proposal of an algorithm for analysis of bone demineralization using synchrotron radiation X-ray μCT images

• Published in: Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2014-02, Vol.95, p.258-260
• Main Authors: Pinheiro, Christiano Jorge Gomes, de Moura Meneses, Anderson Alvarenga, Braz, Delson, de Oliveira, Luís Fernando, Cely Rodrigues Barroso, Regina
• Format: Article
• Language: English
• Subjects: Connectivity; Micro-computed tomography; Synchrotron radiation; Topology; X-Ray
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2013.01.001

Research on radiation effects on bony tissue, osteoporosis and other diseases demands the assessment of bone structures. Synchrotron Radiation (SR) X-ray micro-Computed Tomography (μCT) is an imaging technique that allows the investigation of such structures in the micrometer level. With the high coherence as well as the monochromaticity of the SR beam, it is possible to assess pathological conditions in those structures accurately, providing quantitative information for decision making. Topology and Histomorphometry provide parameters which describe the relationships between pores, canals and the connectivity in structures. Thus, with periodical assessment of the bone structure by SR-μCT imaging, it is possible to verify the evolution of a disease or the impact of a treatment. In the present summary we describe the application of Topology concepts for quantitative assessment of bone structures in the analysis of SR-μCT images acquired at the Elettra Laboratory (Trieste, Italy). ► The characterization of complex 3D structures is a challenge to researchers. ► High-resolution X-ray Computed Tomography systems are employed in a wide range of areas. ► The Synchrotron Radiation beams enables innovative imaging techniques. ► The connectivity is seen as an alternative to analysis surfaces.