Concentrations of vanadium in urine and seminal plasma in relation to semen quality parameters, spermatozoa DNA damage and serum hormone levels

Widespread human exposure to vanadium has been well documented. Vanadium exposure was reported to induce male reproductive toxicity in toxicological studies, yet human epidemiologic studies are lacking. Here we determined the associations between environmental exposure to vanadium and semen quality,...

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Bibliographic Details
Published in:The Science of the total environment 2018-12, Vol.645, p.441-448
Main Authors: Wang, Yi-Xin, Chen, Heng-Gui, Li, Xian-Dong, Chen, Ying-Jun, Liu, Chong, Feng, Wei, Zeng, Qiang, Wang, Peng, Pan, An, Lu, Wen-Qing
Format: Article
Language:English
Subjects:
DNA Damage
Environmental Exposure - analysis
Environmental Exposure - statistics & numerical data
Environmental Pollutants - toxicity
Environmental Pollutants - urine
Gonadal Hormones - blood
Humans
Male
Reproductive hormone
Semen - drug effects
Semen - physiology
Semen Analysis
Semen quality
Spermatozoa
Vanadium
Vanadium - toxicity
Vanadium - urine
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Summary:Widespread human exposure to vanadium has been well documented. Vanadium exposure was reported to induce male reproductive toxicity in toxicological studies, yet human epidemiologic studies are lacking. Here we determined the associations between environmental exposure to vanadium and semen quality, spermatozoa DNA damage and serum reproductive hormones. Concentrations of vanadium in seminal plasma and repeated urine samples were determined among 764 men recruited from a reproductive medicine centre. Associations of vanadium concentrations with semen quality parameters (n = 764), DNA integrity measures (n = 404) and serum reproductive hormones (n = 381) were assessed by logistic or linear regression models with adjustment for potential confounders. Significant positive dose–response relationships were observed between vanadium concentrations in seminal plasma and tail length and serum estradiol, as well as odds ratios for a below-reference-value sperm concentration; whereas inverse relationships between seminal plasma vanadium with total testosterone (T) and free T (all p values for trends
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2018.07.137