Precise molecularly imprinted montmorillonite for selective adsorption of salvianolic acid A with ultra-large capacity

Salvianolic acid A (SAA), a water-soluble phenolic acid compound with high bioactivity in Danshen, is widely used in cardiovascular and cerebrovascular therapy due to its pharmacological effects. We report here a method for efficient adsorption of SAA from aqueous solution by using precise molecular...

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Bibliographic Details
Published in:Surfaces and interfaces 2025-01, Vol.57, p.105741, Article 105741
Main Authors: Wang, Yue, Qian, Jun, Shi, Mengli, Gu, Jianxing, Sheng, Miaomiao, Li, Liqin, Kai, Guoyin
Format: Article
Language:English
Subjects:
Adsorption
Montmorillonite
Precise molecularly imprinting
Salvianolic acid A
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Summary:Salvianolic acid A (SAA), a water-soluble phenolic acid compound with high bioactivity in Danshen, is widely used in cardiovascular and cerebrovascular therapy due to its pharmacological effects. We report here a method for efficient adsorption of SAA from aqueous solution by using precise molecularly imprinted montmorillonite (PIM). The synthesis of PIM follows a sequential imprinting assembly between SAA and functional monomers to precisely control the orientation of imprinting sites, resulting high selectivity of adsorbent for SAA. The adsorption kinetics conform to the pseudo-first-order and pseudo-second-order kinetic models, and adsorption equilibrium can be reached within 10 min at 298.15 K. The Langmuir adsorption isotherm model simulation indicates that the maximum adsorption capacity can reach 1703.4 mg/g. Adsorption mechanism possibly includes covalent bond, electrostatic interaction and hydrogen bond. It can be inferred that multiple interactions along with precise imprinting effects lead to the strong affinity for SAA through comprehensive analysis of density functional theory calculation and practical adsorption performance. This work highlights that PIM is a promising adsorbent for selective SAA capture with large adsorption capacity. [Display omitted]
ISSN:2468-0230
DOI:10.1016/j.surfin.2025.105741