HSF1: Guardian of Proteostasis in Cancer

Proteomic instability is causally related to human diseases. In guarding proteome stability, the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role. Contrasting with its beneficial role of enhancing cell survival, recent findings have revealed a compelling pro-oncog...

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Bibliographic Details
Published in:Trends in cell biology 2016-01, Vol.26 (1), p.17-28
Main Authors: Dai, Chengkai, Sampson, Stephen Byers
Format: Article
Language:English
Subjects:
amyloidogenesis
Animals
DNA-Binding Proteins - physiology
Heat Shock Transcription Factors
Homeostasis
HSF1
Humans
Neoplasms - metabolism
Pathology
Protein Processing, Post-Translational
Proteome - metabolism
proteome homeostasis
proteotoxic stress
Signal Transduction
Transcription Factors - physiology
tumor suppression
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