Enantioselective reduction of α,β-unsaturated ketones by Geotrichum candidum, Mortierella isabellina and Rhodotorula rubra yeast

The reduction of 3-methyl-4-phenyl-3-buten-2-one and its phenyl-substituted derivatives by microorganisms was investigated. Growing cells of Mortierella isabellina DSM1414 and Geotrichum candidum LOCK 105 strains reduced α,β-unsaturated ketones to the corresponding secondary alcohols in high enantio...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2006-08, Vol.17 (13), p.1958-1962
Main Authors: Zagozda, Malgorzata, Plenkiewicz, Jan
Format: Article
Language:English
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Summary:The reduction of 3-methyl-4-phenyl-3-buten-2-one and its phenyl-substituted derivatives by microorganisms was investigated. Growing cells of Mortierella isabellina DSM1414 and Geotrichum candidum LOCK 105 strains reduced α,β-unsaturated ketones to the corresponding secondary alcohols in high enantiomeric excess (94–99%), whereas the Rhodotorula rubra M18D3 strain converted the same compounds into optically active ketones as the major products with only trace amounts of the corresponding saturated and unsaturated alcohols.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2006.06.021