Asymmetric Michael reaction: novel efficient access to chiral β-ketophosphonates

The asymmetric Michael reaction between chiral β-enaminophosphonates derived from ( S)-1-phenylethylamine and various electrophilic alkenes furnished β,β-disubstituted ketophosphonates in good yields and with excellent enantioselectivity.

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2007-03, Vol.18 (5), p.685-691
Main Authors: Delarue-Cochin, Sandrine, Pan, Jian-Jung, Dauteloup, Aurélie, Hendra, Frédéric, Angoh, Roger Gagali, Joseph, Delphine, Stephens, Philip J., Cavé, Christian
Format: Article
Language:English
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Summary:The asymmetric Michael reaction between chiral β-enaminophosphonates derived from ( S)-1-phenylethylamine and various electrophilic alkenes furnished β,β-disubstituted ketophosphonates in good yields and with excellent enantioselectivity.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2007.02.023