Stereoselective synthesis of (3 R,4 S)-3-amino-4-methyl pyrrolidine

A stereoselective approach for the synthesis of (3 R,4 S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivati...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2008-10, Vol.19 (20), p.2402-2405
Main Authors: Jayachitra, G., Anchoori, Ravi Kumar, Rao, B. Venkateswara
Format: Article
Language:English
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Summary:A stereoselective approach for the synthesis of (3 R,4 S)-3-amino-4-methyl pyrrolidine, a part of the structure of a quinoline antibacterial compound and the naphthyridine antitumor agent, is described. The key reaction is the one-pot reduction and regioselective cyclization of azidoditosyl derivative 9 to pyrrolidine 10.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2008.10.005