Enantiomerically pure α-methoxyaryl acetaldehydes as versatile precursors: a facile chemo-enzymatic methodology for their preparation

A facile and efficient synthesis of optically active α-methoxyaryl acetic acids (up to 95% ee), α-methoxyaryl ethanols (up to 93% ee) and α-methoxyaryl acetonitriles (up to 93% ee) was achieved via Arthrobacter sp . lipase-catalyzed kinetic resolution of masked aldehydes as the key synthons, that is...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2008-11, Vol.19 (22), p.2579-2588
Main Authors: Singh, Buddh, Gupta, Pankaj, Chaubey, Asha, Parshad, Rajinder, Sharma, Shiromani, Taneja, Subhash C.
Format: Article
Language:English
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Summary:A facile and efficient synthesis of optically active α-methoxyaryl acetic acids (up to 95% ee), α-methoxyaryl ethanols (up to 93% ee) and α-methoxyaryl acetonitriles (up to 93% ee) was achieved via Arthrobacter sp . lipase-catalyzed kinetic resolution of masked aldehydes as the key synthons, that is, α-hydroxyaryl acetaldehyde acetals.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2008.10.023