Total synthesis of (+)-cladospolide D

[Display omitted] The asymmetric total synthesis of cladospolide D, a natural 12-membered macrolide antibiotic, has been accomplished in 12-steps. Sharpless asymmetric dihydroxylation, Grubb’s cross metathesis, and Shiina lactonization have been employed as the key reactions for the installation of...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2016-03, Vol.27 (4-5), p.222-225
Main Authors: Reddy, Chada Raji, Dilipkumar, Uredi, Mallesh, Kathe, Latha, Bellamkonda, Shravya, Ravula
Format: Article
Language:English
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Summary:[Display omitted] The asymmetric total synthesis of cladospolide D, a natural 12-membered macrolide antibiotic, has been accomplished in 12-steps. Sharpless asymmetric dihydroxylation, Grubb’s cross metathesis, and Shiina lactonization have been employed as the key reactions for the installation of the desired stereocenter and the construction of the macrolactone framework.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2016.01.013