An efficient unprecedented synthesis of novel functionalized imidazoles from secondary amino- N-carbothioic acid (phenyl- p-tolylimino-methyl)amides and dimethyl acetylenedicarboxylate

Novel, unprecedented and single-pot synthesis of functionalized imidazoles possessing secondary amine and carbomethoxy moieties, by the reaction of secondary amino- N-carbothioic acid (phenyl- p-tolylimino-methyl)amides with dimethyl acetylenedicarboxylate under mild conditions is described. The syn...

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Bibliographic Details
Published in:Tetrahedron letters 2004-11, Vol.45 (48), p.8945-8947
Main Authors: Marwaha, Alka, Singh, Parvesh, Mahajan, Mohinder P., Velumurugan, D.
Format: Article
Language:English
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Summary:Novel, unprecedented and single-pot synthesis of functionalized imidazoles possessing secondary amine and carbomethoxy moieties, by the reaction of secondary amino- N-carbothioic acid (phenyl- p-tolylimino-methyl)amides with dimethyl acetylenedicarboxylate under mild conditions is described. The synthesis of functionalized imidazoles in a single-pot from the reactions of secondary amino- N-carbothioic acid (phenyl- p-tolylimino-methyl)amides with dimethyl acetylenedicarboxylate is reported. A plausible mechanistic pathway for the formation of the imidazoles is proposed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.119